A Rationally Designed Universal Catalyst for Suzuki–Miyaura Coupling Processes


  • We thank the National Institutes of Health (GM 46059) for support of this work. We are grateful to Merck, Pfizer, Rhodia, Lundbeck, and Novartis for additional support. T.E.B. would like to thank Dr. W. M. Davis for assistance with the X-ray crystal structure.


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Unprecedented scope, reactivity, and stability are displayed by a new catalyst system. This was demonstrated with general and efficient syntheses of sterically hindered (hetero)biaryls (see examples shown), mild coupling reactions of alkyl boron derivatives, and rapid coupling reactions of aryl chlorides at room temperature.