A Catalytic Approach to (R)-(+)-Muscopyridine with Integrated “Self-Clearance”


  • This work was supported by the Deutsche Forschungsgemeinschaft (Leibniz program) and the Fonds der Chemischen Industrie.


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The integration of various metal-catalyzed reactions into a one-pot processes opens an unprecedentedly short and efficient route to the odoriferous alkaloid (R)-(+)-muscopyridine. Importantly, it is shown how metathesis can be used for a most convenient “self-clearance” of a product mixture (see scheme; OTf=CF3SO3).