Financial support was provided by the National Cancer Institute, US National Institutes of Health (under grant CA44848). We thank Dr. Peter Gantzel, University of California, San Diego, for assistance with X-ray diffraction experiments.
Salinosporamide A: A Highly Cytotoxic Proteasome Inhibitor from a Novel Microbial Source, a Marine Bacterium of the New Genus Salinospora†
Version of Record online: 20 JAN 2003
© 2002 WILEY-VCH Verlag GmbH & Co. KGaA, Weinheim
Angewandte Chemie International Edition
Volume 42, Issue 3, pages 355–357, January 20, 2003
How to Cite
Feling, R. H., Buchanan, G. O., Mincer, T. J., Kauffman, C. A., Jensen, P. R. and Fenical, W. (2003), Salinosporamide A: A Highly Cytotoxic Proteasome Inhibitor from a Novel Microbial Source, a Marine Bacterium of the New Genus Salinospora. Angew. Chem. Int. Ed., 42: 355–357. doi: 10.1002/anie.200390115
- Issue online: 20 JAN 2003
- Version of Record online: 20 JAN 2003
- Manuscript Received: 4 OCT 2002
- 2Actinomycetes in Biotechnology, (Eds.: M. Goodfellow, S. T. Williams, M. Mordarski), Academic Press, New York, 1988, pp. 33–67., in
- 4Crystal Data for 1: C15H21ClNO4, Mr=313.11, monoclinic space group, P21, a=10.4805(6), b=24.2085(13), c=12.5163(7) Å, β=108.603(10)°, V=3009.7(3) Å3, Z=8, ρcalcd=1.385 g cm−3; MoKα radiation, λ=0.71073 Å, μ=0.269 mm−1, T=−100 K. 25 627 data (13 056 unique, Rint=0.0146, θ<27.52°) were collected on a Bruker SMART APEX CCD X-ray diffractometer. The structure was solved by direct methods and refined by full-matrix least-squares on F2 values of all data (G. M. Sheldrick, SHELXTL Manual) to give wR2=0.0824, conventional R=0.0313 for F values of 12 747 reflections, S=1.037 and 773 parameters. Residual electron density max/min 0.448/−0.232 e Å−3. CCDC-183413 (1) contains the supplementary crystallographic data for this paper. These data can be obtained free of charge via www.ccdc.cam.ac.uk/conts/retrieving.html (or from the Cambridge Crystallographic Data Centre, 12 Union Road, Cambridge CB2 1EZ, UK; fax: (+44) 1223-336-033; or firstname.lastname@example.org).
- 10We gratefully acknowledge K. Lloyd, S. Glaser, B. Miller, Nereus Pharmaceuticals Inc., for providing proteasome inhibition data.