The authors gratefully acknowledge funding provided by NSF (Grant CHE-9727566), the Beckman Institute Foundation, the California Institute of Technology, the Camille and Henry Dreyfus Foundation (New Faculty Award to B.M.S.), and Abbott Labs (graduate fellowship to J.A.M.). Special thanks to the Peter Dervan group for aid in the use of their HPLC apparatus.
Molecular Mousetraps: Gas-Phase Studies of the Covalent Coupling of Noncovalent Complexes Initiated by Reactive Carbenes Formed by Controlled Activation of Diazo Precursors†
Article first published online: 26 FEB 2003
© 2002 WILEY-VCH Verlag GmbH & Co. KGaA, Weinheim
Angewandte Chemie International Edition
Volume 42, Issue 9, pages 1012–1015, March 3, 2003
How to Cite
Julian, R. R., May, J. A., Stoltz, B. M. and Beauchamp, J. L. (2003), Molecular Mousetraps: Gas-Phase Studies of the Covalent Coupling of Noncovalent Complexes Initiated by Reactive Carbenes Formed by Controlled Activation of Diazo Precursors. Angew. Chem. Int. Ed., 42: 1012–1015. doi: 10.1002/anie.200390258
- Issue published online: 26 FEB 2003
- Article first published online: 26 FEB 2003
- Manuscript Received: 23 OCT 2002
- amino acids;
- electrospray ionization;
- host–guest systems;
- molecular recognition
The covalent linking of noncovalently bound host–guest complexes in the gas phase is achieved by the formation of a highly reactive carbene from the host molecule, which is generated by collision-activated dissociation. Possible mechanisms for the resulting intermolecular reactions are explored by theory and experiment.