A Versatile Catalyst for the Sonogashira Coupling of Aryl Chlorides

Authors

  • Axel Köllhofer Dipl.-Chem.,

    1. Institut für Anorganische und Physikalische Chemie, Technische Universität Darmstadt, Petersenstrasse 18, 64287 Darmstadt, Germany, Fax: (+49) 6151-16-6040
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  • Thomas Pullmann,

    1. Institut für Anorganische und Physikalische Chemie, Technische Universität Darmstadt, Petersenstrasse 18, 64287 Darmstadt, Germany, Fax: (+49) 6151-16-6040
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  • Herbert Plenio Prof. Dr.

    1. Institut für Anorganische und Physikalische Chemie, Technische Universität Darmstadt, Petersenstrasse 18, 64287 Darmstadt, Germany, Fax: (+49) 6151-16-6040
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  • This work was supported by the Deutsche Forschungsgemeinschaft and the TU Darmstadt.

Abstract

original image

Aryl chlorides are suitable substrates for the Sonogashira coupling! By using the versatile catalyst system Na2[PdCl4]/PR3/CuI (PR3=(1-Ad)2PBn, PtBu3), the Sonogashira coupling [Eq. (a)] of aryl chlorides with alkynes generates excellent yields of the corresponding disubstituted aryl alkynes.

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