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Keywords:

  • amination;
  • azodicarboxylates;
  • catalysis;
  • enantioselectivity;
  • proline
Thumbnail image of graphical abstract

Simple, direct, and highly enantioselective α-amination of carbonyl compounds 1 with azodicarboxylates 2 no longer requires prior enolization of the substrate. The “magic” small-organic-molecule catalyst for this reaction in dichloromethane at room temperature is once again L-proline (3).