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Proline-Catalyzed Asymmetric α-Amination of Aldehydes and Ketones—An Astonishingly Simple Access to Optically Active α-Hydrazino Carbonyl Compounds

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Abstract

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Simple, direct, and highly enantioselective α-amination of carbonyl compounds 1 with azodicarboxylates 2 no longer requires prior enolization of the substrate. The “magic” small-organic-molecule catalyst for this reaction in dichloromethane at room temperature is once again L-proline (3).

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