This work was financially supported in part by a Grant-in-Aid for Scientific Research in the Priority Area of “Molecular Synchronization for Design of New Materials System” (No. 404/11167270, 13022258) from the Ministry of Education, Culture, Sports, Science and Technology, Japan.
Time-Controlled Desorption of Ultrathin Polymer Films Triggered by Enzymatic Degradation†
Article first published online: 10 MAR 2003
© 2002 WILEY-VCH Verlag GmbH & Co. KGaA, Weinheim
Angewandte Chemie International Edition
Volume 42, Issue 10, pages 1115–1118, March 10, 2003
How to Cite
Serizawa, T., Yamaguchi, M. and Akashi, M. (2003), Time-Controlled Desorption of Ultrathin Polymer Films Triggered by Enzymatic Degradation. Angew. Chem. Int. Ed., 42: 1115–1118. doi: 10.1002/anie.200390293
- Issue published online: 10 MAR 2003
- Article first published online: 10 MAR 2003
- Manuscript Received: 7 OCT 2002
- enzyme catalysis;
- layered compounds;
- ultrathin films
Degrading films: Surface-component-dependent and time-controlled degradation of a layer-by-layer (LbL) assembly comprising DNA and a cationic synthetic polymer is demonstrated through enzymatic hydrolysis by DNase I (see picture). The negatively charged enzyme is preserved on the cationic polymer surface in an inactive state, and changes in the concentrations of the essential Mg2+ and Ca2+ ions are used to control the activity of the enzyme, and thus control the desorption of the assembly.