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Review
Interactions with Aromatic Rings in Chemical and Biological Recognition
Article first published online: 13 MAR 2003
DOI: 10.1002/anie.200390319
© 2002 WILEY-VCH Verlag GmbH & Co. KGaA, Weinheim
Additional Information
How to Cite
Meyer, E. A., Castellano, R. K. and Diederich, F. (2003), Interactions with Aromatic Rings in Chemical and Biological Recognition . Angew. Chem. Int. Ed., 42: 1210–1250. doi: 10.1002/anie.200390319
Publication History
- Issue published online: 13 MAR 2003
- Article first published online: 13 MAR 2003
- Manuscript Received: 4 NOV 2002
- Abstract
- Article
- References
- Cited By
Keywords:
- arenes;
- hydrogen bonds;
- molecular recognition;
- noncovalent interactions;
- receptors
Abstract
Intermolecular interactions involving aromatic rings are key processes in both chemical and biological recognition. Their understanding is essential for rational drug design and lead optimization in medicinal chemistry. Different approaches—biological studies, molecular recognition studies with artificial receptors, crystallographic database mining, gas-phase studies, and theoretical calculations—are pursued to generate a profound understanding of the structural and energetic parameters of individual recognition modes involving aromatic rings. This review attempts to combine and summarize the knowledge gained from these investigations. The review focuses mainly on examples with biological relevance since one of its aims it to enhance the knowledge of molecular recognition forces that is essential for drug development.