Cover Picture: Diastereoselective Temporary Silicon-Tethered Ring-Closing-Metathesis Reactions with Prochiral Alcohols: A New Approach to Long-Range Asymmetric Induction (Angew. Chem. Int. Ed. 15/2003)

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Abstract

Taking control of stereochemistry should lead to an enhanced understanding of the conformational aspects that affect diastereoselectivity in medium-sized ring systems. The temporary silicon-tethered ring-closing-metathesis reactions described by P. A. Evans et al. on page 1734 ff. represent a new strategy for long-range asymmetric induction that provides a useful approach to 1,4-, 1,5-, and 1,6-stereocontrol.

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