Cover Picture: Multicenter Strategy for the Development of Catalytic Enantioselective Nucleophilic Alkylation of Ketones: Me2Zn Addition to α-Ketoesters (Angew. Chem. Int. Ed. 44/2003)

Authors

  • Ken Funabashi,

    1. Graduate School of Pharmaceutical Sciences, The University of Tokyo, Hongo, Bunkyo-Ku, Tokyo 113-0033, Japan, Fax: (+81) 3-5684-5206
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  • Markus Jachmann Dr.,

    1. Graduate School of Pharmaceutical Sciences, The University of Tokyo, Hongo, Bunkyo-Ku, Tokyo 113-0033, Japan, Fax: (+81) 3-5684-5206
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  • Motomu Kanai Dr.,

    1. Graduate School of Pharmaceutical Sciences, The University of Tokyo, Hongo, Bunkyo-Ku, Tokyo 113-0033, Japan, Fax: (+81) 3-5684-5206
    2. PRESTO, Japan Science and Technology Corporation, Graduate School of Pharmaceutical Sciences, The University of Tokyo, Hongo, Bunkyo-Ku, Tokyo 113-0033, Japan
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  • Masakatsu Shibasaki Prof. Dr.

    1. Graduate School of Pharmaceutical Sciences, The University of Tokyo, Hongo, Bunkyo-Ku, Tokyo 113-0033, Japan, Fax: (+81) 3-5684-5206
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Abstract

The Senjyu Kannon statue in the Koufukuji temple in Nara, Japan (see picture), has thousands of hands to manipulate thousands of things at once. A new catalyst, a 2,4-cis-hydroxyprolinol derivative, was developed for the enantioselective addition of dimethylzinc to α-ketoesters. The catalyst has three hands in a cis-stereochemical array, which activates both the ketoester substrate and the organozinc reagent simultaneously. M. Shibasaki et al. describe on page 5489 ff. the excellent enantioselectivities obtained from aromatic and heteroaromatic substrates.>

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