The illustration on the frontispiece is taken from the codex The Book of Chess, Dice, and Board Games, completed around 1280 by Alfonso X of Castille. Alfonso's heritage represents above all a great cultural bridge between the Christian West and the Muslim East. In a similar way, organocatalysis represents a link between two major forms of catalysis: metal-complex-mediated and enzymatic catalysis, and thus between synthetic and bioorganic chemistry.
In the Golden Age of Organocatalysis†
Article first published online: 29 SEP 2004
Copyright © 2004 WILEY-VCH Verlag GmbH & Co. KGaA, Weinheim
Angewandte Chemie International Edition
Volume 43, Issue 39, pages 5138–5175, October 4, 2004
How to Cite
Dalko, P. I. and Moisan, L. (2004), In the Golden Age of Organocatalysis. Angew. Chem. Int. Ed., 43: 5138–5175. doi: 10.1002/anie.200400650
- Issue published online: 29 SEP 2004
- Article first published online: 29 SEP 2004
- Manuscript Received: 19 JAN 2004
- asymmetric catalysis;
- chiral auxiliaries;
- synthetic methods
The term “organocatalysis” describes the acceleration of chemical reactions through the addition of a substoichiometric quantity of an organic compound. The interest in this field has increased spectacularly in the last few years as result of both the novelty of the concept and, more importantly, the fact that the efficiency and selectivity of many organocatalytic reactions meet the standards of established organic reactions. Organocatalytic reactions are becoming powerful tools in the construction of complex molecular skeletons. The diverse examples show that in recent years organocatalysis has developed within organic chemistry into its own subdiscipline, whose “Golden Age” has already dawned.