Multivalency in the Gas Phase: The Study of Dendritic Aggregates by Mass Spectrometry

Authors

  • Maarten A. C. Broeren,

    1. Laboratory of Macromolecular and Organic Chemistry, Eindhoven University of Technology, P.O. Box 513, 5600 MB, Eindhoven, The Netherlands, Fax: (+31) 40-245-1036
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  • Joost L. J. van Dongen,

    1. Laboratory of Macromolecular and Organic Chemistry, Eindhoven University of Technology, P.O. Box 513, 5600 MB, Eindhoven, The Netherlands, Fax: (+31) 40-245-1036
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  • Michael Pittelkow,

    1. Laboratory of Macromolecular and Organic Chemistry, Eindhoven University of Technology, P.O. Box 513, 5600 MB, Eindhoven, The Netherlands, Fax: (+31) 40-245-1036
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  • Jørn B. Christensen Dr.,

    1. Laboratory of Macromolecular and Organic Chemistry, Eindhoven University of Technology, P.O. Box 513, 5600 MB, Eindhoven, The Netherlands, Fax: (+31) 40-245-1036
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  • Marcel H. P. van Genderen Dr.,

    1. Laboratory of Macromolecular and Organic Chemistry, Eindhoven University of Technology, P.O. Box 513, 5600 MB, Eindhoven, The Netherlands, Fax: (+31) 40-245-1036
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  • E. W. Meijer Prof.

    1. Laboratory of Macromolecular and Organic Chemistry, Eindhoven University of Technology, P.O. Box 513, 5600 MB, Eindhoven, The Netherlands, Fax: (+31) 40-245-1036
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  • We acknowledge grants from the department of Biomedical Engineering of Eindhoven University, the Council for Chemical Science of The Netherlands Organization for Science Research (CW-NWO), and The Danish Natural Research Council (SNF). We thank Dr. U. Boas for providing us with the tripeptides, B.F.M. de Waal for his synthetic help, and Prof. N. M. M. Nibbering for useful discussions.

Abstract

original image

Selective guest ejection: Up to eight guest molecules are assembled at the periphery of a third-generation dendrimer. Collision-induced dissociation mass spectrometry has demonstrated that the guests are removed very selectively in a one-by-one manner (see spectrum).

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