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Total Synthesis of Xerulinic Acid

Authors


  • This work was financially supported by the Fonds der Chemischen Industrie. We are grateful to Dr. Manfred Keller for valuable spectroscopic support and to Melanie Waldrich for technical assistance.

Abstract

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An inhibitor of the biosynthesis of cholesterol, xerulinic acid, has been synthesized for the first time. The convergent approach applied involves the palladium-catalyzed coupling of an enediynoic ester building block, a conjunctive C6 bisstannane, and a bromine-containing methylenebutenolide (see scheme; R=Me3SiCH2CH2).

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