Get access

Total Synthesis of Xerulinic Acid


  • This work was financially supported by the Fonds der Chemischen Industrie. We are grateful to Dr. Manfred Keller for valuable spectroscopic support and to Melanie Waldrich for technical assistance.


original image

An inhibitor of the biosynthesis of cholesterol, xerulinic acid, has been synthesized for the first time. The convergent approach applied involves the palladium-catalyzed coupling of an enediynoic ester building block, a conjunctive C6 bisstannane, and a bromine-containing methylenebutenolide (see scheme; R=Me3SiCH2CH2).

Get access to the full text of this article