Communication

High-Content Peptide Microarrays for Deciphering Kinase Specificity and Biology

  1. Mike Schutkowski Dr.1,
  2. Ulf Reimer Dr.1,
  3. Sören Panse1,
  4. Liying Dong Dr.1,
  5. Jose M. Lizcano Dr.2,
  6. Dario R. Alessi Prof. Dr.2,
  7. Jens Schneider-Mergener Prof. Dr.1,3

Article first published online: 5 MAY 2004

DOI: 10.1002/anie.200453900

Issue

Angewandte Chemie International Edition

Angewandte Chemie International Edition

Volume 43, Issue 20, pages 2671–2674, May 10, 2004

Additional Information

How to Cite

Schutkowski, M., Reimer, U., Panse, S., Dong, L., Lizcano, J. M., Alessi, D. R. and Schneider-Mergener, J. (2004), High-Content Peptide Microarrays for Deciphering Kinase Specificity and Biology. Angewandte Chemie International Edition, 43: 2671–2674. doi: 10.1002/anie.200453900

Author Information

  1. 1

    Jerini AG, Invalidenstrasse 130, 10115 Berlin, Germany, Fax: (+49) 30-97893-105

  2. 2

    Medical Research Council Protein Phosphorylation Unit, MSI/WTB Complex, University of Dundee, Dow Street, Dundee DD1 5EH, UK

  3. 3

    Institut für Medizinische Immunologie, Charité Universitätsmedizin Berlin, 10098 Berlin, Germany

Publication History

  1. Issue published online: 5 MAY 2004
  2. Article first published online: 5 MAY 2004
  3. Manuscript Received: 2 FEB 2004

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Keywords:

  • enzymes;
  • high-throughput screening;
  • microarrays;
  • peptides;
  • substrate specificity

Graphical Abstract

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Thousands of kinase assays at one stroke are possible by using high-content peptide microarrays. Such experiments deliver information regarding peptidic kinase substrates and accelerate the development of high-throughput screening assays. Moreover, knowledge-based selection of human sequences allows the reliable detection of downstream targets of protein kinases, as demonstrated for 3-phosphoinositide-dependent protein kinase.

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