We thank the National Institute of General Medical Sciences, the National Institutes of Health (GM 28284), the National Science Foundation (CHE-9985553), the W. M. Keck Foundation, the Skaggs Institute for Chemical Biology, the MRSEC Program of the National Science Foundation (award no. DMR-0213618 for the Center for Polymeric Interfaces and Macromolecular Assemblies), the NIRT Program of the National Science Foundation (grant no. 0210247), IBM Corporation, DOE-BES, and NSF International/DAAD for financial support. We are also grateful to Prof. M. G. Finn for helpful discussions.
Efficiency and Fidelity in a Click-Chemistry Route to Triazole Dendrimers by the Copper(I)-Catalyzed Ligation of Azides and Alkynes†
Article first published online: 30 JUN 2004
Copyright © 2004 WILEY-VCH Verlag GmbH & Co. KGaA, Weinheim
Angewandte Chemie International Edition
Volume 43, Issue 30, pages 3928–3932, July 26, 2004
How to Cite
Wu, P., Feldman, A. K., Nugent, A. K., Hawker, C. J., Scheel, A., Voit, B., Pyun, J., Fréchet, J. M. J., Sharpless, K. B. and Fokin, V. V. (2004), Efficiency and Fidelity in a Click-Chemistry Route to Triazole Dendrimers by the Copper(I)-Catalyzed Ligation of Azides and Alkynes. Angew. Chem. Int. Ed., 43: 3928–3932. doi: 10.1002/anie.200454078
- Issue published online: 20 JUL 2004
- Article first published online: 30 JUN 2004
- Manuscript Received: 23 FEB 2004
- click chemistry;
Components that click: A large number of diverse dendrimers (see scheme) was prepared in almost quantitative yield by the click-chemistry transformation described in the title. In some cases filtration or solvent extraction was the only method required for purification in this highly efficient construction of the triazole units of the dendrimers.