We thank the Fonds der Chemischen Industrie and Merck Research Laboratories (MSD) for financial support. We also thank V. Malakhov for performing some preliminary experiments as well as Chemetall GmbH (Frankfurt), Wacker Chemie GmbH (München), BASF AG (Ludwigshafen), and Bayer-Chemicals AG for generous gifts of chemicals.
A LiCl-Mediated Br/Mg Exchange Reaction for the Preparation of Functionalized Aryl- and Heteroarylmagnesium Compounds from Organic Bromides†
Article first published online: 26 MAY 2004
Copyright © 2004 WILEY-VCH Verlag GmbH & Co. KGaA, Weinheim
Angewandte Chemie International Edition
Volume 43, Issue 25, pages 3333–3336, June 21, 2004
How to Cite
Krasovskiy, A. and Knochel, P. (2004), A LiCl-Mediated Br/Mg Exchange Reaction for the Preparation of Functionalized Aryl- and Heteroarylmagnesium Compounds from Organic Bromides. Angew. Chem. Int. Ed., 43: 3333–3336. doi: 10.1002/anie.200454084
- Issue published online: 15 JUN 2004
- Article first published online: 26 MAY 2004
- Manuscript Received: 23 FEB 2004
- CC coupling;
- Grignard reaction;
A wide range of aryl and heteroaryl bromides, which are usually sluggish in exchange reactions, are readily converted into the corresponding Grignard reagents by means of a Br/Mg exchange reaction triggered by iPrMgCl⋅LiCl (see scheme). These Grignard intermediates react with electrophiles in good yields.