This research was supported by a grant (CHE-9800445) from the National Science Foundation. High-resolution mass spectra were provided by the University of California, San Francisco. X-ray crystallographic data was collected at the University of California, Berkeley (CHEXRAY). Fellowship assistance from Eli Lilly and Co. (N.M.D. and T.J.W.) is gratefully acknowledged.
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Communication
Intermolecular Dienyl Pauson–Khand Reaction†
Article first published online: 13 MAY 2004
DOI: 10.1002/anie.200454117
Copyright © 2004 WILEY-VCH Verlag GmbH & Co. KGaA, Weinheim
Additional Information
How to Cite
Wender, P. A., Deschamps, N. M. and Williams, T. J. (2004), Intermolecular Dienyl Pauson–Khand Reaction. Angew. Chem. Int. Ed., 43: 3076–3079. doi: 10.1002/anie.200454117
- †
Publication History
- Issue published online: 1 JUN 2004
- Article first published online: 13 MAY 2004
- Manuscript Received: 26 FEB 2004
Keywords:
- cycloaddition;
- dienes;
- multicomponent reactions;
- Pauson–Khand reaction;
- rhodium
Three-component [2+2+1] cycloadditions are facilitated by the use of dienes as activated two-carbon-atom components in a RhI-catalyzed intermolecular variant of the Pauson–Khand reaction (see scheme). The enhanced reactivity of the dienes allows efficient access to a variety of alkenyl cyclopentenones from commercially or readily available starting materials. R1, R2=alkyl, silyl, carbonyl; R3=Me, Bn.