This research was supported by a grant (CHE-9800445) from the National Science Foundation. High-resolution mass spectra were provided by the University of California, San Francisco. X-ray crystallographic data was collected at the University of California, Berkeley (CHEXRAY). Fellowship assistance from Eli Lilly and Co. (N.M.D. and T.J.W.) is gratefully acknowledged.
Intermolecular Dienyl Pauson–Khand Reaction†
Article first published online: 13 MAY 2004
Copyright © 2004 WILEY-VCH Verlag GmbH & Co. KGaA, Weinheim
Angewandte Chemie International Edition
Volume 43, Issue 23, pages 3076–3079, June 7, 2004
How to Cite
Wender, P. A., Deschamps, N. M. and Williams, T. J. (2004), Intermolecular Dienyl Pauson–Khand Reaction. Angew. Chem. Int. Ed., 43: 3076–3079. doi: 10.1002/anie.200454117
- Issue published online: 1 JUN 2004
- Article first published online: 13 MAY 2004
- Manuscript Received: 26 FEB 2004
- multicomponent reactions;
- Pauson–Khand reaction;
Three-component [2+2+1] cycloadditions are facilitated by the use of dienes as activated two-carbon-atom components in a RhI-catalyzed intermolecular variant of the Pauson–Khand reaction (see scheme). The enhanced reactivity of the dienes allows efficient access to a variety of alkenyl cyclopentenones from commercially or readily available starting materials. R1, R2=alkyl, silyl, carbonyl; R3=Me, Bn.