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Communication
A Flexible, Palladium-Catalyzed Indole and Azaindole Synthesis by Direct Annulation of Chloroanilines and Chloroaminopyridines with Ketones
Article first published online: 25 AUG 2004
DOI: 10.1002/anie.200460122
Copyright © 2004 WILEY-VCH Verlag GmbH & Co. KGaA, Weinheim
Additional Information
How to Cite
Nazaré, M., Schneider, C., Lindenschmidt, A. and Will, D. W. (2004), A Flexible, Palladium-Catalyzed Indole and Azaindole Synthesis by Direct Annulation of Chloroanilines and Chloroaminopyridines with Ketones. Angew. Chem. Int. Ed., 43: 4526–4528. doi: 10.1002/anie.200460122
Publication History
- Issue published online: 25 AUG 2004
- Article first published online: 25 AUG 2004
- Manuscript Revised: 26 MAY 2004
- Manuscript Received: 25 MAR 2004
Keywords:
- annulation;
- cyclization;
- indoles;
- nitrogen heterocycles;
- palladium
The “ringmaster” [Pd(tBu3P)2] serves as the catalyst in the direct synthesis of indoles by annulation of ortho-chloroanilines with ketones (see picture). This versatile method can be used to synthesize a variety of functionalized indoles and azaindoles. DMA=dimethylacetamide.