A Combinatorial Approach to Catalytic Peptide Dendrimers


  • This work was financially supported by the University of Bern and the Swiss National Science Foundation. We thank Mr. Urs Kämpfer of the Protein Analytical Service of the Department of Chemistry and Biochemistry, University of Bern, for performing the amino acid analyses.


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Exploring the structural diversity of peptide dendrimers as synthetic protein models: A 65 536-membered combinatorial peptide-dendrimer library was prepared by split-and-mix techniques on beads (see picture). The library was screened and revealed peptide dendrimers that catalyze fluorogenic ester hydrolysis and peptide dendrimers that bind to vitamin B12.