Genetic Control by a Natural Metabolite-Responsive Ribozyme


  • The author acknowledges the Austrian Science Fund (FWF) for generous funding.


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Another striking example for the functional diversity of RNA is represented by the recently discovered riboswitch ribozyme in the leader sequence of bacterial mRNAs. A simple mechanism is responsible for controlling expression of the corresponding gene (see scheme) and demonstrates that gene regulation is no longer a domain necessarily assisted by proteins.