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Keywords:

  • asymmetric synthesis;
  • cyclopropanation;
  • nitrogen heterocycles;
  • organocatalysis;
  • ylides
Thumbnail image of graphical abstract

Highly functionalized cyclopropanes can be produced with excellent enantioselectivity through an amine-catalyzed organocatalytic cyclopropanation process (see scheme). Catalytically generated asymmetric ammonium ylides mediate the reaction, and the cyclopropane products can be produced as either enantiomer by using quinine- or quinidine-derived catalysts.