Efficient Whole-Cell Biotransformation in a Biphasic Ionic Liquid/Water System

Authors


  • We are grateful to Solvent Innovation for providing us with the ionic liquids. This work was supported by the German Federal Ministry of Education and Research (grant no. 0312737E).

Abstract

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Biocompatible ionic liquids act as a substrate reservoir and an in situ extracting agent in biotransformations with whole cells (see scheme). In the reduction of 4-chloroacetophenone to (R)-1-(4-chlorophenyl)ethanol, high product concentration (82 g L−1) and purity (99.6 % ee) were achieved without the addition of cofactors and without damaging the biocatalyst.

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