We are grateful to Rhone-Poulenc SA (contract no. 041313.00), Aventis CropScience SA, and Bayer CropScience SA for the financial support of this study.
Simple Synthesis of Nodulation-Factor Analogues Exhibiting High Affinity towards a Specific Binding Protein†
Article first published online: 1 SEP 2004
Copyright © 2004 WILEY-VCH Verlag GmbH & Co. KGaA, Weinheim
Angewandte Chemie International Edition
Volume 43, Issue 35, pages 4644–4646, September 6, 2004
How to Cite
Grenouillat, N., Vauzeilles, B., Bono, J.-J., Samain, E. and Beau, J.-M. (2004), Simple Synthesis of Nodulation-Factor Analogues Exhibiting High Affinity towards a Specific Binding Protein. Angew. Chem. Int. Ed., 43: 4644–4646. doi: 10.1002/anie.200460275
- Issue published online: 1 SEP 2004
- Article first published online: 1 SEP 2004
- Manuscript Received: 8 APR 2004
- aromatic substitution;
- lipid analogues;
- nitrogen fixation;
A “Nod” in the right direction: Aromatic analogues of the lipooligosaccharidic nodulation (Nod) factors involved in the symbiosis of Sinorhizobium meliloti and legumes are easily assembled from very simple precursors by combining biotechnological and chemical procedures. Some of these analogues (see structure) bind tightly to a specific binding protein and form a new class of glycolipid mimics.