Simple Synthesis of Nodulation-Factor Analogues Exhibiting High Affinity towards a Specific Binding Protein

Authors

  • Nathalie Grenouillat,

    1. Université Paris-Sud, Laboratoire de Synthèse de Biomolécules associé au CNRS, Institut de Chimie Moléculaire et des Matériaux, 91405 Orsay Cedex, France, Fax: (+33) 1-6985-3715
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  • Boris Vauzeilles Dr.,

    1. Université Paris-Sud, Laboratoire de Synthèse de Biomolécules associé au CNRS, Institut de Chimie Moléculaire et des Matériaux, 91405 Orsay Cedex, France, Fax: (+33) 1-6985-3715
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  • Jean-Jacques Bono Dr.,

    1. Pôle de Biotechnologie Végétale, UMR 5546 CNRS–Université Paul Sabatier, 24, Chemin de Borde Rouge, BP 17 Auzeville, 31326 Castanet-Tolosan, France
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  • Eric Samain Dr.,

    1. Centre de Recherches sur les Macromolécules Végétales, UPR CNRS 5301, BP 53, 38041 Grenoble Cedex 9, France
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  • Jean-Marie Beau Prof.

    1. Université Paris-Sud, Laboratoire de Synthèse de Biomolécules associé au CNRS, Institut de Chimie Moléculaire et des Matériaux, 91405 Orsay Cedex, France, Fax: (+33) 1-6985-3715
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  • We are grateful to Rhone-Poulenc SA (contract no. 041313.00), Aventis CropScience SA, and Bayer CropScience SA for the financial support of this study.

Abstract

original image

A “Nod” in the right direction: Aromatic analogues of the lipooligosaccharidic nodulation (Nod) factors involved in the symbiosis of Sinorhizobium meliloti and legumes are easily assembled from very simple precursors by combining biotechnological and chemical procedures. Some of these analogues (see structure) bind tightly to a specific binding protein and form a new class of glycolipid mimics.

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