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Keywords:

  • allylations;
  • aminations;
  • asymmetric catalysis;
  • iridium;
  • regioselectivity
Thumbnail image of graphical abstract

Highly regio- and enantioselective allylation of aromatic amines is observed when a cyclometalated Ir–phosphoramidite complex is generated in situ (see scheme). The active catalyst can be formed from [{Ir(cod)Cl}2] and ligand L with a volatile alkylamine prior to addition of the reagents or upon use of a tertiary amine additive.