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Keywords:

  • allylation;
  • asymmetric synthesis;
  • heterocycles;
  • homogenous catalysis;
  • palladium
Thumbnail image of graphical abstract

Excellent yields and enantioselectivies are attained in the synthesis of 3-alkyl-3-aryl oxindoles based on the Pd-catalyzed asymmetric allylic alkylation (AAA) reaction. This approach utilizes a nonbasic hydroxylic additive in the transformation of 3-aryl oxindoles into complex, synthetically valuable oxindoles (see scheme).