Generation of Dynamic Constitutional Diversity and Driven Evolution in Helical Molecular Strands under Lewis Acid Catalyzed Component Exchange


  • This work was supported by a predoctoral fellowship from the Ministère de la Jeunesse, de la Recherche et de la Technologie (J.-L.S.).


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A stir in the library: The efficient Sc(OTf)3-catalyzed transimination of helical oligohydrazone strands has been utilized to yield a highly diverse constitutional dynamic library through assembly, dissociation, and exchange of components. This library can subsequently undergo driven evolution in the presence of ZnII ions to express preferentially [2×2] gridlike arrays by component recombination.