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The Isolation and Crystal Structure of a Cyclic Selenenate Ester Derived from Bis(2,6-diformyl-4-tert-butylphenyl)diselenide and its Glutathione Peroxidase-Like Activity

Authors


  • We thank the Department of Science and Technology (DST), India. S.S.Z. would like to thank the Council for Scientific and Industrial Research (CSIR), India, for a fellowship.

Abstract

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Enzyme mimicry: Halogenation of diselenide 1 affords the cyclic selenenate ester 2 (see scheme) through a highly unstable selenenic acid intermediate. Compound 2 exhibits a strong intramolecular nonbonding Se⋅⋅⋅O interaction. Both 1 and 2 show excellent glutathione peroxidase-like catalytic activity.

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