Get access

Dihydrogen Trioxide (HOOOH) Is Generated during the Thermal Reaction between Hydrogen Peroxide and Ozone

Authors

  • Paul T. Nyffeler,

    1. Department of Chemistry & The Skaggs Institute for Chemical Biology, The Scripps Research Institute, 10550 N. Torrey Pines Rd., La Jolla, CA92037, USA, Fax: (+1) 858-784-2590
    Search for more papers by this author
  • Nicholas A. Boyle Dr.,

    1. Department of Chemistry & The Skaggs Institute for Chemical Biology, The Scripps Research Institute, 10550 N. Torrey Pines Rd., La Jolla, CA92037, USA, Fax: (+1) 858-784-2590
    Search for more papers by this author
  • Laxman Eltepu Dr.,

    1. Department of Chemistry & The Skaggs Institute for Chemical Biology, The Scripps Research Institute, 10550 N. Torrey Pines Rd., La Jolla, CA92037, USA, Fax: (+1) 858-784-2590
    Search for more papers by this author
  • Chi-Huey Wong Prof.,

    1. Department of Chemistry & The Skaggs Institute for Chemical Biology, The Scripps Research Institute, 10550 N. Torrey Pines Rd., La Jolla, CA92037, USA, Fax: (+1) 858-784-2590
    Search for more papers by this author
  • Albert Eschenmoser Prof.,

    1. Laboratorium für organische Chemie, Eidgenössische Technische Hochschule (ETH), Hönggerberg HCl-H309, Universitaetstrasse 16 8093 Zürich, Switzerland
    Search for more papers by this author
  • Richard A. Lerner Prof.,

    1. Department of Chemistry & The Skaggs Institute for Chemical Biology, The Scripps Research Institute, 10550 N. Torrey Pines Rd., La Jolla, CA92037, USA, Fax: (+1) 858-784-2590
    Search for more papers by this author
  • Paul Wentworth Jr. Prof.

    1. Department of Chemistry & The Skaggs Institute for Chemical Biology, The Scripps Research Institute, 10550 N. Torrey Pines Rd., La Jolla, CA92037, USA, Fax: (+1) 858-784-2590
    2. Oxford Glycobiology Institute, Department of Biochemistry, University of Oxford, South Parks Rd., Oxford, OX1 3QU, UK
    Search for more papers by this author

  • This work was supported by the Skaggs Institute for Chemical Biology. P.W. thanks the members of The Scripps Research Institute NMR facility, especially Dr. D. Huang and Dr. L. Pasternack, for expert assistance during this study.

Abstract

original image

Quantifiable amounts of HOOOH can be detected by 1H NMR spectroscopic analysis of the thermal reaction of O3 and HOOH (see scheme). This first experimental report of a link between these three oxidants suggests that HOOOH may be involved in oxidation reactions that span biological, atmospheric, and environmental systems.

Ancillary