Generous financial support from the Deutsche Forschungsgemeinschaft (Leibniz Award Program) and the Fonds der Chemischen Industrie is gratefully acknowledged. R.M. thanks the Alexander-von-Humboldt Foundation for a postdoctoral fellowship. We express our gratitude to Prof. K. Jonas, Mülheim, for valuable discussions and for providing a generous sample of the iron complex 1, as well as to Dr. A. Leitner for performing preliminary experiments.
Cross-Coupling of Alkyl Halides with Aryl Grignard Reagents Catalyzed by a Low-Valent Iron Complex†
Article first published online: 7 JUL 2004
Copyright © 2004 WILEY-VCH Verlag GmbH & Co. KGaA, Weinheim
Angewandte Chemie International Edition
Volume 43, Issue 30, pages 3955–3957, July 26, 2004
How to Cite
Martin, R. and Fürstner, A. (2004), Cross-Coupling of Alkyl Halides with Aryl Grignard Reagents Catalyzed by a Low-Valent Iron Complex. Angew. Chem. Int. Ed., 43: 3955–3957. doi: 10.1002/anie.200460504
- Issue published online: 20 JUL 2004
- Article first published online: 7 JUL 2004
- Manuscript Received: 29 APR 2004
- alkyl halides;
- Grignard reagents;
A striking reversal of the usual reactivity pattern of aryl Grignard reagents is observed for reactions in the presence of catalytic amounts of the “bare” ferrate complex [Li(tmeda)]2[Fe(C2H4)4] (1). Highly reduced iron–magnesium clusters may play a decisive role in the exceptionally facile and chemoselective cross-coupling reaction with alkyl halides (see scheme).