Unveiling Reliable Catalysts for the Asymmetric Nitroaldol (Henry) Reaction

Authors

  • Claudio Palomo Prof. Dr.,

    1. Departamento de Química Orgánica I, Facultad de Química, Universidad del País Vasco, Apdo. 1072, 20080 San Sebastián, Spain, Fax: (+34) 943-015270
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  • Mikel Oiarbide Prof. Dr.,

    1. Departamento de Química Orgánica I, Facultad de Química, Universidad del País Vasco, Apdo. 1072, 20080 San Sebastián, Spain, Fax: (+34) 943-015270
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  • Antonia Mielgo Dr.

    1. Departamento de Química Orgánica I, Facultad de Química, Universidad del País Vasco, Apdo. 1072, 20080 San Sebastián, Spain, Fax: (+34) 943-015270
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  • We thank The University of the Basque Country (EHU/UPV) and the Ministerio de Ciencia y Tecnología (Spain) for support of this work.

Abstract

original image

Conceptually different chiral catalysts ranging from polymetallic complexes to Lewis acids and organocatalysts have emerged for solving the long-standing problem of stereocontrol in the Henry reaction, a fundamental C[BOND]C bond-forming process (see scheme). New catalyst systems with improved selectivity have increased the synthetic value of this reaction considerably.

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