We thank The University of the Basque Country (EHU/UPV) and the Ministerio de Ciencia y Tecnología (Spain) for support of this work.
Unveiling Reliable Catalysts for the Asymmetric Nitroaldol (Henry) Reaction†
Article first published online: 28 SEP 2004
Copyright © 2004 WILEY-VCH Verlag GmbH & Co. KGaA, Weinheim
Angewandte Chemie International Edition
Volume 43, Issue 41, pages 5442–5444, October 18, 2004
How to Cite
Palomo, C., Oiarbide, M. and Mielgo, A. (2004), Unveiling Reliable Catalysts for the Asymmetric Nitroaldol (Henry) Reaction. Angew. Chem. Int. Ed., 43: 5442–5444. doi: 10.1002/anie.200460506
- Issue published online: 13 OCT 2004
- Article first published online: 28 SEP 2004
- asymmetric catalysis;
- CC bond formation;
- Henry reaction;
- nitroaldol reaction;
- synthetic methods
Conceptually different chiral catalysts ranging from polymetallic complexes to Lewis acids and organocatalysts have emerged for solving the long-standing problem of stereocontrol in the Henry reaction, a fundamental CC bond-forming process (see scheme). New catalyst systems with improved selectivity have increased the synthetic value of this reaction considerably.