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Keywords:

  • asymmetric catalysis;
  • C[BOND]C bond formation;
  • Henry reaction;
  • nitroaldol reaction;
  • synthetic methods
Thumbnail image of graphical abstract

Conceptually different chiral catalysts ranging from polymetallic complexes to Lewis acids and organocatalysts have emerged for solving the long-standing problem of stereocontrol in the Henry reaction, a fundamental C[BOND]C bond-forming process (see scheme). New catalyst systems with improved selectivity have increased the synthetic value of this reaction considerably.