Micrometer-Sized Spherical Assemblies of Polypeptides and Small Molecules by Acid–Base Chemistry

Authors

  • Brandon J. McKenna,

    1. Department of Chemistry and Biochemistry, University of California, Santa Barbara, CA-93106-9510, USA, Fax: (+1) 805-8934120
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    • These authors contributed equally to the present work.

  • Henrik Birkedal Dr.,

    1. Department of Chemistry and Biochemistry, University of California, Santa Barbara, CA-93106-9510, USA, Fax: (+1) 805-8934120
    2. Present address: Department of Chemistry, University of Aarhus, Langelandsgade 140, 8000 Aarhus C, Denmark, Fax: (+45) 86196199
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    • These authors contributed equally to the present work.

  • Michael H. Bartl Dr.,

    1. California NanoSystems Institute, University of California, Santa Barbara, CA-93106, USA
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  • Timothy J. Deming Prof.,

    1. Department of Chemistry and Biochemistry and Materials Department, University of California, Santa Barbara, CA-93106, USA
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  • Galen D. Stucky Prof.

    1. Department of Chemistry and Biochemistry and Materials Department, University of California, Santa Barbara, CA-93106, USA
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  • This work was partially supported by the MRSEC program of the National Science Foundation under Award No. DMR00-80034 and made use of MRL Central Facilities under this program. This work was also supported in part by the U.S. Army Research Laboratory and the U.S. Army Research Office under contract number DAAD19–03-D-0004, as well as NASA University Research, Engineering and Technology Institute on Bio-Inspired Materials (BIMat) under award No. NCC-1-02037. Financial assistance from the Danish Natural Sciences Research Council (H.B.) and a Max-Kade research fellowship from the Austrian Academy of Sciences (M.H.B.) are gratefully acknowledged.

Abstract

original image

Spontaneous formation of microspheres is observed when charged poly(amino acid)s are combined with certain oppositely charged, multivalent organic ions. The surfaces of the spheres are chemically active and act as templates for silica condensation, and the assemblies can be made hollow or polymer-filled, depending on the silica precursor (see image; the fluorescent polymer forms a layer inside a colloidal-silica-coated sphere).

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