Communication

A Unidirectional DNA Walker That Moves Autonomously along a Track†

  1. Peng Yin1,
  2. Hao Yan Prof.1,
  3. Xiaoju G. Daniell1,
  4. Andrew J. Turberfield Prof.2,
  5. John H. Reif Prof.1

Article first published online: 30 AUG 2004

DOI: 10.1002/anie.200460522

Issue

Angewandte Chemie International Edition

Angewandte Chemie International Edition

Volume 43, Issue 37, pages 4906–4911, September 20, 2004

Additional Information

How to Cite

Yin, P., Yan, H., Daniell, X. G., Turberfield, A. J. and Reif, J. H. (2004), A Unidirectional DNA Walker That Moves Autonomously along a Track. Angew. Chem. Int. Ed., 43: 4906–4911. doi: 10.1002/anie.200460522

Author Information

  1. 1

    Department of Computer Science, Duke University, Durham, NC 27708, USA, Fax: (+1) 919-660-6519

  2. 2

    Department of Physics, Clarendon Laboratory, University of Oxford, Parks Road, Oxford OX1 3PU, UK, Fax: (+44) 1-865-272

  1. †

    This work was supported by a grant from the NSF (EIA-0218359) to H.Y. and J.H.R., by NSF ITR grants EIA-0086015 and CCR-0326157, and by DARPA/AFSOR Contract F30602-01-2-0561.

Publication History

  1. Issue published online: 16 SEP 2004
  2. Article first published online: 30 AUG 2004
  3. Manuscript Received: 30 APR 2004

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Keywords:

  • DNA;
  • molecular devices;
  • nanorobotics;
  • nanostructures;
  • self-assembly
Thumbnail image of graphical abstract

There's no turning back for an autonomous DNA walker that moves along a self-assembled track, driven by the hydrolysis of ATP. The track contains three anchorages (A, B, C) at which the walker (★), a six-nucleotide DNA fragment, can be bound (see figure). The motion of the walker is unidirectional. At each step it is ligated to the next anchorage, then cut from the previous one by a restriction endonuclease.

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