This work was supported by a grant from the NSF (EIA-0218359) to H.Y. and J.H.R., by NSF ITR grants EIA-0086015 and CCR-0326157, and by DARPA/AFSOR Contract F30602-01-2-0561.
A Unidirectional DNA Walker That Moves Autonomously along a Track†
Article first published online: 30 AUG 2004
Copyright © 2004 WILEY-VCH Verlag GmbH & Co. KGaA, Weinheim
Angewandte Chemie International Edition
Volume 43, Issue 37, pages 4906–4911, September 20, 2004
How to Cite
Yin, P., Yan, H., Daniell, X. G., Turberfield, A. J. and Reif, J. H. (2004), A Unidirectional DNA Walker That Moves Autonomously along a Track. Angew. Chem. Int. Ed., 43: 4906–4911. doi: 10.1002/anie.200460522
- Issue published online: 16 SEP 2004
- Article first published online: 30 AUG 2004
- Manuscript Received: 30 APR 2004
- molecular devices;
There's no turning back for an autonomous DNA walker that moves along a self-assembled track, driven by the hydrolysis of ATP. The track contains three anchorages (A, B, C) at which the walker (★), a six-nucleotide DNA fragment, can be bound (see figure). The motion of the walker is unidirectional. At each step it is ligated to the next anchorage, then cut from the previous one by a restriction endonuclease.