We are thankful for the financial support of The University of Hong Kong (Generic Drugs Research Program), the Area of Excellence Scheme (AoE 10/01P) administered by the University Grants Council (HKSAR), and the Hong Kong Research Grants Council (HKU7099/01P). J.C. thanks the Croucher Foundation of Hong Kong for a postgraduate studentship.
A Practical and Mild Method for the Highly Selective Conversion of Terminal Alkenes into Aldehydes through Epoxidation–Isomerization with Ruthenium(IV)–Porphyrin Catalysts†
Article first published online: 16 SEP 2004
Copyright © 2004 WILEY-VCH Verlag GmbH & Co. KGaA, Weinheim
Angewandte Chemie International Edition
Volume 43, Issue 37, pages 4950–4954, September 20, 2004
How to Cite
Chen, J. and Che, C.-M. (2004), A Practical and Mild Method for the Highly Selective Conversion of Terminal Alkenes into Aldehydes through Epoxidation–Isomerization with Ruthenium(IV)–Porphyrin Catalysts. Angew. Chem. Int. Ed., 43: 4950–4954. doi: 10.1002/anie.200460545
- Issue published online: 16 SEP 2004
- Article first published online: 16 SEP 2004
- Manuscript Received: 4 MAY 2004
- homogeneous catalysis;
- N ligands;
Aldehydes in excellent yields were obtained from the ruthenium–porphyrin-catalyzed oxidation of various terminal alkenes with 2,6-dichloropyridine N-oxide under mild conditions. The aldehydes generated from these ruthenium-catalyzed alkene oxidations can be used in situ for olefination reactions with ethyl diazoacetate in the presence of PPh3 in a one-pot diazoacetate olefination starting from alkenes (see example).