The authors thank N. Bodzin for assistance with graphics as well as W. Han and R. Zalpuri for help with TEM experiments. This work was supported by the Director, Office of Energy Research, Office of Basic Energy Sciences, Division of Materials Sciences, of the US Department of Energy under Contract No. DE-AC03-76SF00098, within the Interfacing Nanostructures Initiative.
Biomimetic Engineering of Carbon Nanotubes by Using Cell Surface Mucin Mimics†
Article first published online: 17 NOV 2004
Copyright © 2004 WILEY-VCH Verlag GmbH & Co. KGaA, Weinheim
Angewandte Chemie International Edition
Volume 43, Issue 45, pages 6111–6116, November 19, 2004
How to Cite
Chen, X., Lee, G. S., Zettl, A. and Bertozzi, C. R. (2004), Biomimetic Engineering of Carbon Nanotubes by Using Cell Surface Mucin Mimics. Angew. Chem. Int. Ed., 43: 6111–6116. doi: 10.1002/anie.200460620
- Issue published online: 17 NOV 2004
- Article first published online: 17 NOV 2004
- Manuscript Received: 11 MAY 2004
- biomimetic synthesis;
- bioorganic chemistry;
Biocompatible nanotubes: Glycosylated polymers designed to mimic natural mucins were assembled on carbon nanotubes (see picture). Carbon nanotubes coated with mucin mimics were soluble in water, resisted nonspecific protein binding, and bound specifically to biomolecules through receptor–ligand interactions.