Communication

Biomimetic Engineering of Carbon Nanotubes by Using Cell Surface Mucin Mimics†

  1. Xing Chen3,
  2. Goo Soo Lee Dr.3,
  3. A. Zettl Prof.1,
  4. Carolyn R. Bertozzi Prof.2

Article first published online: 17 NOV 2004

DOI: 10.1002/anie.200460620

Issue

Angewandte Chemie International Edition

Angewandte Chemie International Edition

Volume 43, Issue 45, pages 6111–6116, November 19, 2004

Additional Information

How to Cite

Chen, X., Lee, G. S., Zettl, A. and Bertozzi, C. R. (2004), Biomimetic Engineering of Carbon Nanotubes by Using Cell Surface Mucin Mimics. Angew. Chem. Int. Ed., 43: 6111–6116. doi: 10.1002/anie.200460620

Author Information

  1. 1

    Department of Physics, University of California and Materials Sciences Division, Lawrence Berkeley National Laboratory, Berkeley, CA 94720, USA, Fax: (+1) 510-643-8497

  2. 2

    Departments of Chemistry and Molecular and Cell Biology, and Howard Hughes Medical Institute, University of California, and Materials Sciences Division, Lawrence Berkeley National Laboratory, Berkeley, CA 94720, USA, Fax: (+1) 510-643-2628

  3. 3

    Department of Chemistry, University of California and Materials Sciences Division, Lawrence Berkeley National Laboratory, Berkeley, CA 94720, USA

  1. †

    The authors thank N. Bodzin for assistance with graphics as well as W. Han and R. Zalpuri for help with TEM experiments. This work was supported by the Director, Office of Energy Research, Office of Basic Energy Sciences, Division of Materials Sciences, of the US Department of Energy under Contract No. DE-AC03-76SF00098, within the Interfacing Nanostructures Initiative.

Publication History

  1. Issue published online: 17 NOV 2004
  2. Article first published online: 17 NOV 2004
  3. Manuscript Received: 11 MAY 2004

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Keywords:

  • biomimetic synthesis;
  • bioorganic chemistry;
  • glycoproteins;
  • nanotubes
Thumbnail image of graphical abstract

Biocompatible nanotubes: Glycosylated polymers designed to mimic natural mucins were assembled on carbon nanotubes (see picture). Carbon nanotubes coated with mucin mimics were soluble in water, resisted nonspecific protein binding, and bound specifically to biomolecules through receptor–ligand interactions.

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