Changes in the Conductance of Single Peptide Molecules upon Metal-Ion Binding


  • We thank the NSF (CHE-0243423) and the DOE (DE-FG03-01ER45943) for financial support to B.Q.X. and X.Y.X., respectively.


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The binding of a guest (metal ion, M+) to a single host molecule (peptide) was studied by the measurement of the conductance of the peptide (see picture). The conductance of the peptide in the metal–peptide complexes increases by an amount that is dependent on the sequence and the length of the host.