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Reversibly Addressing an Allosteric Catalyst In Situ: Catalytic Molecular Tweezers


  • CAM acknowledges the NSF and AFOSR for support of this work. SHC acknowledges the DOE for funding through the Institute for Environmental Catlysis (Grant no. DE-FG02-03ER15457)


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Abiotic allosteric regulation: The design, synthesis, and application of novel, reversible allosteric catalytic molecular tweezers that contain a structural metal, addressable in situ, and two functional catalytic metals are reported (see picture). Kinetic and selectivity data reflect a significant decrease in cooperativity upon opening of the “arms” of the catalyst caused by reactions occurring at the hinge.