We are grateful to the Fonds der Chemischen Industrie and to the Deutsche Forschungsgemeinschaft (DFG, within SFB 380 “Asymmetric Synthesis by Chemical and Biological Methods”) for financial support.
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Communication
C1-Symmetric Sulfoximines as Ligands in Copper-Catalyzed Asymmetric Mukaiyama-Type Aldol Reactions†
Article first published online: 10 NOV 2004
DOI: 10.1002/anie.200460953
Copyright © 2004 WILEY-VCH Verlag GmbH & Co. KGaA, Weinheim
Issue
Angewandte Chemie International Edition
Volume 43, Issue 44, pages 5984–5987, November 12, 2004
Additional Information
How to Cite
Langner, M. and Bolm, C. (2004), C1-Symmetric Sulfoximines as Ligands in Copper-Catalyzed Asymmetric Mukaiyama-Type Aldol Reactions. Angewandte Chemie International Edition, 43: 5984–5987. doi: 10.1002/anie.200460953
- †
Publication History
- Issue published online: 10 NOV 2004
- Article first published online: 10 NOV 2004
- Manuscript Received: 14 JUN 2004
Keywords:
- aldol reaction;
- asymmetric catalysis;
- copper;
- N ligands;
- sulfoximines
Graphical Abstract
Aldol products with quarternary centers have been obtained with up to 99 % ee in high yields by using copper(II) catalysts bearing C1-symmetric aminosulfoximines as ligands (see scheme). In terms of ee values and yield the new catalysts compare well with established systems based on metal complexes with bis(oxazoline) and pyridylbis(oxazoline) ligands.