We are grateful for financial support from the Swedish Research Council, the Swedish Foundation for Strategic Research, and the Ministerio de Educación y Ciencia of Spain.
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Highly Compatible Metal and Enzyme Catalysts for Efficient Dynamic Kinetic Resolution of Alcohols at Ambient Temperature†
Article first published online: 1 DEC 2004
DOI: 10.1002/anie.200461416
Copyright © 2004 WILEY-VCH Verlag GmbH & Co. KGaA, Weinheim
Additional Information
How to Cite
Martín-Matute, B., Edin, M., Bogár, K. and Bäckvall, J.-E. (2004), Highly Compatible Metal and Enzyme Catalysts for Efficient Dynamic Kinetic Resolution of Alcohols at Ambient Temperature. Angewandte Chemie International Edition, 43: 6535–6539. doi: 10.1002/anie.200461416
- †
Publication History
- Issue published online: 1 DEC 2004
- Article first published online: 1 DEC 2004
- Manuscript Received: 23 JUL 2004
Keywords:
- enantioselectivity;
- enzyme catalysis;
- kinetic resolution;
- reaction mechanisms;
- ruthenium
Graphical Abstract
The combination of highly compatible metal and enzyme catalysts allows the fastest dynamic kinetic resolution of alcohols ever reported. The use of ruthenium catalyst 1 a (or 1 b) and an immobilized lipase results in a highly efficient enantioselective synthesis of acetates in excellent yields at room temperature (see scheme).