Communication

You have free access to this content

The Composition of Ehrlich's Salvarsan: Resolution of a Century-Old Debate†

  1. Nicholas C. Lloyd,
  2. Hugh W. Morgan Prof.,
  3. Brian K. Nicholson Prof.,
  4. Ron S. Ronimus Dr.

Article first published online: 29 DEC 2004

DOI: 10.1002/anie.200461471

Issue

Angewandte Chemie International Edition

Angewandte Chemie International Edition

Volume 44, Issue 6, pages 941–944, January 28, 2005

Additional Information

How to Cite

Lloyd, N. C., Morgan, H. W., Nicholson, B. K. and Ronimus, R. S. (2005), The Composition of Ehrlich's Salvarsan: Resolution of a Century-Old Debate. Angewandte Chemie International Edition, 44: 941–944. doi: 10.1002/anie.200461471

Author Information

  1. Departments of Chemistry and Biological Sciences, University of Waikato, Private Bag 3105, Hamilton, New Zealand, Fax: (+64) 7-838-4219

  1. †

    We thank the Marsden Fund, administered by the Royal Society of New Zealand, for financial support.

Publication History

  1. Issue published online: 25 JAN 2005
  2. Article first published online: 29 DEC 2004
  3. Manuscript Revised: 8 OCT 2004
  4. Manuscript Received: 29 JUL 2004

SEARCH

SEARCH BY CITATION

ARTICLE TOOLS

View Full Article (HTML) Get PDF (101K)

Keywords:

  • arsenic;
  • arsphenamine;
  • mass spectrometry;
  • salvarsan;
  • structure elucidation

Graphical Abstract

Thumbnail image of graphical abstract

Elusive molecular structure revealed: The primary components of the historically important pharmaceutical compound salvarsan (arsphenamine, Ehrlich 606) have been shown by ESI mass spectrometry to be cyclopolyarsines [RAs]n (see structure; n=3–6 and R=3-amino-4-hydroxyphenyl).

View Full Article (HTML) Get PDF (101K)