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Bromide-Assisted Oxidation of Substituted Phenols with Hydrogen Peroxide to the Corresponding p-Quinol and p-Quinol Ethers over WO42−-Exchanged Layered Double Hydroxides

Authors

  • B. F. Sels Prof.,

    1. Department of Interphase Chemistry, Centre for Surface Chemistry and Catalysis, Katholieke Universtiteit Leuven, Kasteelpark Arenberg 23, 3001, Heverlee, Belgium, Fax: (+32) 16-321-998
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  • D. E. De Vos Prof.,

    1. Department of Interphase Chemistry, Centre for Surface Chemistry and Catalysis, Katholieke Universtiteit Leuven, Kasteelpark Arenberg 23, 3001, Heverlee, Belgium, Fax: (+32) 16-321-998
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  • P. A. Jacobs Prof.

    1. Department of Interphase Chemistry, Centre for Surface Chemistry and Catalysis, Katholieke Universtiteit Leuven, Kasteelpark Arenberg 23, 3001, Heverlee, Belgium, Fax: (+32) 16-321-998
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  • The authors thank the FWO-Vlaanderen (BFS) for a postdoctoral fellowship and Roeland Vancutsem for skilful technical assistance. This work was performed in the frame of the IAP program “Supramolecular Chemistry and Catalysis” of the Belgian Federal government.

Abstract

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A simple and efficient one-pot synthesis of p-quinols and their ethers occurs over tungstate-exchanged layered double hydroxides (WO42−-LDHs), which catalyze the bromide-assisted oxidation of substituted phenols to the corresponding 4-alkoxy- and 4-hydroxycyclohexa-2,5-dienones in high yields (see scheme).

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