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Multifunctional Nanoparticles Possessing A “Magnetic Motor Effect” for Drug or Gene Delivery

Authors

  • Tae-Jong Yoon,

    1. Materials Chemistry Laboratory, School of Chemistry, Seoul National University, Seoul, 151-747, Korea, Fax: (+82) 2-882-1080
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    • These authors contributed equally to this work.

  • Jun Sung Kim,

    1. Laboratory of Toxicology, College of Veterinary Medicine and School of Agricultural Biotechnology, Seoul National University, Seoul, 151-747, Korea, Fax: (+82) 2-873-1268
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    • These authors contributed equally to this work.

  • Byung Geol Kim,

    1. Materials Chemistry Laboratory, School of Chemistry, Seoul National University, Seoul, 151-747, Korea, Fax: (+82) 2-882-1080
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  • Kyeong Nam Yu,

    1. Laboratory of Toxicology, College of Veterinary Medicine and School of Agricultural Biotechnology, Seoul National University, Seoul, 151-747, Korea, Fax: (+82) 2-873-1268
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  • Myung-Haing Cho Prof.,

    1. Laboratory of Toxicology, College of Veterinary Medicine and School of Agricultural Biotechnology, Seoul National University, Seoul, 151-747, Korea, Fax: (+82) 2-873-1268
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  • Jin-Kyu Lee Prof.

    1. Materials Chemistry Laboratory, School of Chemistry, Seoul National University, Seoul, 151-747, Korea, Fax: (+82) 2-882-1080
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  • This work is supported by Nano Systems Institute-National Core Research Center (NSI-NCRC), Korea Science and Engineering Foundation (KOSEF). T.-J.Y, J.S.K, B.-G.K, and K.N.Y are grateful for the award of a BK21 fellowship. We thank Prof. Seung Bum Park for his valuable comments and Ms. Eun Jung Kang for her help with CLSM investigations. “Magnetic motor effect”: cell movement as a result of applying an external magnetic field to cells containing magnetic nanoparticles.

Abstract

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Cells in motion: Multifunctional nanoparticles, with a unique combination of magnetic and fluorescent properties, coupled with biocompatibility are prepared. The uptake of the magnetic nanoparticles by cells is investigated, and an external “magnetic motor effect” on the cells containing the nanoparticles is observed (see scheme).

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