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Iron-Catalyzed Aryl–Aryl Cross-Couplings with Magnesium-Derived Copper Reagents

Authors

  • Ioannis Sapountzis Dr.,

    1. Department Chemie, Ludwig Maximilians-Universität München, Butenandtstrasse 5–13, Haus F, 81 377 München, Germany, Fax: (+49) 89-2180-77680
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  • Wenwei Lin Dipl.-Chem.,

    1. Department Chemie, Ludwig Maximilians-Universität München, Butenandtstrasse 5–13, Haus F, 81 377 München, Germany, Fax: (+49) 89-2180-77680
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  • Christiane C. Kofink Dipl.-Chem.,

    1. Department Chemie, Ludwig Maximilians-Universität München, Butenandtstrasse 5–13, Haus F, 81 377 München, Germany, Fax: (+49) 89-2180-77680
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  • Christina Despotopoulou,

    1. Department Chemie, Ludwig Maximilians-Universität München, Butenandtstrasse 5–13, Haus F, 81 377 München, Germany, Fax: (+49) 89-2180-77680
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  • Paul Knochel Prof. Dr.

    1. Department Chemie, Ludwig Maximilians-Universität München, Butenandtstrasse 5–13, Haus F, 81 377 München, Germany, Fax: (+49) 89-2180-77680
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  • We thank the Fonds der Chemischen Industrie, the Deutsche Forschungsgemeinschaft (DFG), and Merck Research Laboratories (MSD) for financial support. I.S. thanks Aventis Pharma (Frankfurt a. M.) for a fellowship. We also thank Chemetall GmbH (Frankfurt), Wacker Chemie GmbH (München), BASF AG (Ludwigshafen), and Bayer Chemicals AG for generous gifts of chemicals.

Abstract

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Well-matched couples: Functionalized aryl and heteroaryl copper species obtained from the corresponding magnesium derivatives undergo Fe-catalyzed cross-coupling reactions with aryl iodides that bear keto, ester, triflate, or nitrile groups (see scheme).

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