Highly Rigid Diphosphane Ligands with a Large Dihedral Angle Based on a Chiral Spirobifluorene Backbone


  • We thank the National Natural Science Foundation of China, the Major Basic Research Development Program (Grant G2000077506), the Ministry of Education of China, and the Committee of Science and Technology of Tianjin for financial support.


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High and wide: The high rigidity and large dihedral angle of chiral, spirobifluorene-based diphosphane ligands lead to excellent reactivity and enantioselectivity in the ruthenium-catalyzed asymmetric hydrogenation of α,β-unsaturated carboxylic acids (see scheme).