Stereocontrolled Total Synthesis of (−)-Aurisides A and B

Authors


  • This research was supported by the EPSRC, Emmanuel College, Cambridge (Research Fellowship to G.J.F), the EC (Network HPRN-CT-2000-18), and Merck Research Laboratories.

Abstract

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An expedient total synthesis of aurisides A and B (1), unusual cytotoxic macrolide glycosides isolated from the Japanese sea hare D. auricularia, takes advantage of a highly convergent aldol-based route for the stereocontrolled construction of the common macrolide core. This is followed by α-selective glycosylation to introduce the sugar moieties.

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