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Recent Advances in Catalytic, Enantioselective α Aminations and α Oxygenations of Carbonyl Compounds

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  • The author would like to thank Prof. Hisashi Yamamoto (University of Chicago) for helpful discussions.

Abstract

The direct introduction of either a nitrogen or oxygen atom adjacent to a carbonyl group in a catalytic, enantioselective manner using both chiral Lewis acid and Lewis base catalysis has been described recently. The enantiomerically enriched products of these reactions, such as α-amino acids, represent fundamental building blocks for the construction of complex natural products and other important bioactive molecules. This Minireview provides a synopsis of this ever-growing field and highlights some of the challenges that still remain.

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