Communication

Convergent Diversity-Oriented Synthesis of Small-Molecule Hybrids†

  1. Chuo Chen Dr.‡,
  2. Xiaodong Li‡,
  3. Christopher S. Neumann,
  4. Michael M.-C. Lo Dr.,
  5. Stuart L. Schreiber Prof.

Article first published online: 3 MAR 2005

DOI: 10.1002/anie.200462798

Issue

Angewandte Chemie International Edition

Angewandte Chemie International Edition

Volume 44, Issue 15, pages 2249–2252, April 8, 2005

Additional Information

How to Cite

Chen, C., Li, X., Neumann, C. S., Lo, M. M.-C. and Schreiber, S. L. (2005), Convergent Diversity-Oriented Synthesis of Small-Molecule Hybrids. Angew. Chem. Int. Ed., 44: 2249–2252. doi: 10.1002/anie.200462798

Author Information

  1. Howard Hughes Medical Institute, Department of Chemistry and Chemical Biology, Harvard University and The Broad Institute of Harvard and MIT, 12 Oxford Street, Cambridge, MA 02138, USA, Fax: (+1) 617-495-0751

  1. ‡

    These authors contributed equally to this work.

  1. †

    We thank the NIGMS for support of this research. C.C. is a research associate and S.L.S is an investigator with the Howard Hughes Medical Institute at the Department of Chemistry and Chemical Biology, Harvard University. C.S.N. acknowledges an NSF predoctoral fellowship.

  2. ‡

    These authors contributed equally to this work.

Publication History

  1. Issue published online: 6 APR 2005
  2. Article first published online: 3 MAR 2005
  3. Manuscript Received: 3 DEC 2004

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Keywords:

  • convergent synthesis;
  • diversity-oriented synthesis;
  • polycycles;
  • small-molecule hybrids;
  • solid-phase synthesis
Thumbnail image of graphical abstract

Complex small-molecule libraries were constructed by a convergent approach with a short linear sequence: a 480-membered bridged-piperidine/fused-pyrrolidine hybrid library IV and a 384-membered spirocyclic-oxindole/fused-pyrrolidine hybrid library V from the sublibrary II and the sublibraries I and III, respectively. II=RII[BOND]COOH.

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