We thank Brandeis University for financial support, and the Camille and Henry Dreyfus Foundation for a New Faculty Award.
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Communication
Palladium-Catalyzed Asymmetric Iodination of Unactivated C![[BOND]](http://onlinelibrarystatic.wiley.com/undisplayable_characters/00f8ff.gif)
H Bonds under Mild Conditions†
Article first published online: 23 FEB 2005
DOI: 10.1002/anie.200462884
Copyright © 2005 WILEY-VCH Verlag GmbH & Co. KGaA, Weinheim
Additional Information
How to Cite
Giri, R., Chen, X. and Yu, J.-Q. (2005), Palladium-Catalyzed Asymmetric Iodination of Unactivated CH Bonds under Mild Conditions. Angew. Chem. Int. Ed., 44: 2112–2115. doi: 10.1002/anie.200462884
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Publication History
- Issue published online: 22 MAR 2005
- Article first published online: 23 FEB 2005
- Manuscript Received: 10 DEC 2004
Keywords:
- asymmetric catalysis;
- C-H activation;
- chiral auxiliaries;
- iodine;
- palladium
Specific, asymmetric, and mild: Oxazoline (Oxa), a removable chelating chiral auxiliary, assists in the asymmetric activation of C(sp3)H bonds at the β position and C(sp2)H bonds at the γ position. Pd(OAc)2 is an effective catalyst for the selective and asymmetric iodination of methyl, cyclopropyl, and aryl groups at room temperature (see formulae).