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Keywords:

  • adenosine monophosphate;
  • bioluminescence;
  • enzymes;
  • firefly luciferase;
  • total synthesis
Thumbnail image of graphical abstract

Shedding light on luciferase: Luciferyl coenzyme A (1) was synthesized and it was found that luciferase catalyzes light production from luciferyl coenzyme A and AMP. The results of this study open perspectives for new bioanalytical methods and are strong evidence for the evolutionary relationship between firefly luciferase and acyl-CoA synthetases.