DNA-Encoded Self-Assembly of Gold Nanoparticles into One-Dimensional Arrays


  • This work was supported by the NSF (EIA-0323452), the DARPA/DSO (MDA 972-03-1-0020), and Purdue University (a start-up fund). The AFM study was carried out in Purdue Laboratory for Chemical Nanotechnology (PLCN). We thank Prof. A. Ivanisevic for use of an AFM in some cases. EM imaging was conducted at Purdue electron microscopy consortium.


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Strands of gold: Extended one-dimensional arrays of gold nanoparticles up to 4 μm long can be assembled by hybridization between thiolated DNA/nanoparticle 1:1 conjugates and long DNA templates, which were prepared by rolling-circle polymerization (see picture). The linear self-assembled structures could link the nanometric properties of materials with the convenience of micrometric manipulation.